10.60507/FK2/WB6DOI
Mohammadi, Ali
Ali
Mohammadi
University of Bonn
Fuhrmann, Falko
Falko
Fuhrmann
Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.
Tillmann, Jens F.
Jens F.
Tillmann
University of Bonn
Fuhrmann, Martin
Martin
Fuhrmann
Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.
Schwarz, Martin K.
Martin K.
Schwarz
University of Bonn
The Diagonal Band of Broca Regulates Olfactory-mediated Social Behaviors: A Study Using USVs As Unbiased, Ethological Markers For Social Interactions
bonndata
2025
Medicine, Health and Life Sciences
Schwarz, Martin K.
Martin K.
Schwarz
University of Bonn
2025-08-13
2025-08-14
2025-08-28
10.1101/2020.11.07.372649
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1.1
Creative Commons Attribution 4.0 International License.
The Horizontal Diagonal Band of Broca (HDB) modulates olfactory information processing by recruiting olfactory bulb (OB) interneurons to shape excitatory OB output. Here, we show that OB is strongly and differentially innervated by HDB projections. Light-induced silencing of HDB afferents in the OB via OPN3 affected olfactory-mediated social habituation and discrimination behaviors, as shown by manual annotation of investigative behavior.
Additionally, we established ultrasonic vocalizations (USVs) as an unbiased, reliable, and ethologically relevant biomarker for quantifying investigative social behavior. To this end, we employed "DeepFisFis," an AI-based solution, developed in our lab for detection of mouse USVs.
Collectively, our studies demonstrate that USVs serve as an effective biomarker for investigative social behavior. Furthermore, our results highlight the HDB as a crucial top-down relay in the modulation of olfactory-mediated social behaviors.