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Part 1: Document Description
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Citation |
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Title: |
Image data related to publication "Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism" |
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Identification Number: |
doi:10.60507/FK2/M42B8O |
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Distributor: |
bonndata |
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Date of Distribution: |
2026-01-21 |
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Version: |
1 |
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Bibliographic Citation: |
Makdissi, Nikola; Viola, Maria Francesca; Mass, Elvira, 2026, "Image data related to publication "Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism"", https://doi.org/10.60507/FK2/M42B8O, bonndata, V1 |
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Citation |
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Title: |
Image data related to publication "Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism" |
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Identification Number: |
doi:10.60507/FK2/M42B8O |
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Authoring Entity: |
Makdissi, Nikola (University of Bonn) |
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Viola, Maria Francesca (University of Bonn) |
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Mass, Elvira (University of Bonn) |
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Other identifications and acknowledgements: |
Dagmar Wachten |
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Other identifications and acknowledgements: |
Virginia Aliprandi |
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Other identifications and acknowledgements: |
Marina Mayer |
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Other identifications and acknowledgements: |
Katharina Sieckmann |
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Other identifications and acknowledgements: |
Nele Kronau |
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Grant Number: |
851257 |
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Grant Number: |
ATLF 873-2023 |
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Grant Number: |
GRK1873/2 |
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Distributor: |
bonndata |
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Access Authority: |
Mass, Elvira |
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Depositor: |
Makdissi, Nikola |
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Date of Deposit: |
2025-12-20 |
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Holdings Information: |
https://doi.org/10.60507/FK2/M42B8O |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Medicine, Health and Life Sciences |
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Abstract: |
Plastic pollution is an emerging yet understudied environmental risk to the immune system. Once ingested, nano- and microplastic particles (MNPs) can translocate from the gut to internal organs, with macrophages serving as primary targets. Kupffer cells (KCs), the liver-resident macrophages, play a central role in immune surveillance and metabolism, yet their response to MNPs remains unclear. Here, using a chronic plastic exposure model in mice, we identify KCs as the primary hepatic reservoir for MNPs. Long-term exposure alters their transcriptional profile and impairs phagocytic function, leading to metabolic dysregulation of hepatocytes. Microplastics, but not nanoplastics, reduce KC-mediated clearance of circulating cells and bacteria. Under diet-induced obesity, microplastics exacerbates hepatic lipid accumulation, while nanoplastics impair systemic glucose metabolism. Although the blood-brain barrier limits microplastic infiltration, a small fraction of ingested nanoplastics reaches the brain, where it is taken up by microglia, the brain-resident macrophages. However, we observe no signs of neuroinflammation or behavioral deficits. These findings demonstrate that chronic MNP exposure disrupts macrophage function in a size-dependent manner, with distinct consequences for liver and systemic metabolism, while the brain remains largely protected. Understanding tissue-specific vulnerabilities to MNPs is crucial for assessing their long-term health impact. |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Notes: |
<a href="http://creativecommons.org/licenses/by/4.0">CC BY 4.0</a> |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Title: |
Nikola Makdissi, Maria Francesca Viola, Lisa Steinheuer et al. Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism, PREPRINT (Version 1) available at Research Square |
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Identification Number: |
10.21203/rs.3.rs-6204281/v1 |
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Bibliographic Citation: |
Nikola Makdissi, Maria Francesca Viola, Lisa Steinheuer et al. Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism, PREPRINT (Version 1) available at Research Square |
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Label: |
GFAP_MP.zip |
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Notes: |
application/zip |
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Label: |
GFAP_NP.zip |
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Notes: |
application/zip |
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Label: |
GFAP_PBS.zip |
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Notes: |
application/zip |
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Label: |
gWAT_HE_NMPingestion.zip |
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Notes: |
application/zip |
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Label: |
IF_NMPingestion_Clec4f-DTR.zip |
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Notes: |
application/zip |
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Label: |
InsulinIHC_NMP_HFDingestion.zip |
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Notes: |
application/zip |
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ORO_NMPingestion.zip |
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Notes: |
application/zip |
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PAS_NMPingestion.zip |
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Notes: |
application/zip |
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Label: |
Readme_Makdissi_Viola_ ImageData_PlasticExposure.txt |
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Notes: |
text/plain |