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Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks

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Persistent identifier
doi:10.60507/FK2/KB2RN6
Published version
1.0
Publication date
2025-09-04
License
CC BY 4.0

Description

The temporal order of a sequence of events has been thought to be reflected in the ordered firing of neurons at different phases of theta oscillations. Here we assess this by measuring single neuron activity (1,420 neurons) and local field potentials (921 channels) in the medial temporal lobe of 16 patients with epilepsy performing a working-memory task for temporal order. During memory maintenance, we observe theta oscillations, preferential firing of single neurons to theta phase and a close relationship between phase of firing and item position. However, the firing order did not match item order. Training recurrent neural networks to perform an analogous task, we also show the generation of theta oscillations, theta phase-dependent firing related to item position and, again, no match between firing and item order. Rather, our results suggest a mechanistic link between phase order, stimulus timing and oscillation frequency. In both biological and artificial neural networks, we provide evidence supporting the role of phase of firing in working-memory processing.

Creators

Keywords

Cognitive neuroscience, Network models, Working memory

Files

Before downloading: Use and redistribution are governed by CC BY 4.0. Review and comply with the license before using the data.
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sequence-memory-main.zipapplication/zip284048MD5 2b0af4a85622332befc6c139debd7229

Citation

Mormann, Florian; Liebe, Stefanie; Niediek, Johannes; Reber, Thomas; Faber, Jennifer; Elger, Christian E.; Pals, Matthijs; Macke, Jakob H.; Boström, Jan, 2025-09-04, Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks, doi:10.60507/FK2/KB2RN6, V1.0

Additional Dataverse fields

Id474
Dataset Typedataset
Internal Version Number8
Latest Version Publishing StateRELEASED
Release Time2025-09-04T10:20:24Z
Create Time2025-09-04T10:18:51Z
Citation Date2025-09-04
File Access RequestTrue

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Complete Dataverse metadata

Citation Metadata

Title title
Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks
Alternative URL alternativeURL
https://github.com/mackelab/sequence-memory
Author author
  1. Author Name
    Mormann, Florian
    Author Affiliation
    University of Bonn Medical Center
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0003-1305-8028
    Expandedvalue
    Person Name
    Mormann, Florian
    @id
    https://orcid.org/0000-0003-1305-8028
    Scheme
    ORCID
    @type
    https://schema.org/Person
  2. Author Name
    Liebe, Stefanie
    Author Affiliation
    University of Bonn Medical Center
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0003-2873-2943
    Expandedvalue
    Person Name
    Liebe, Stefanie
    @id
    https://orcid.org/0000-0003-2873-2943
    Scheme
    ORCID
    @type
    https://schema.org/Person
  3. Author Name
    Niediek, Johannes
    Author Affiliation
    University of Bonn Medical Center
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0003-3323-2986
    Expandedvalue
    Person Name
    Niediek, Johannes
    @id
    https://orcid.org/0000-0003-3323-2986
    Scheme
    ORCID
    @type
    https://schema.org/Person
  4. Author Name
    Reber, Thomas
    Author Affiliation
    University of Bonn Medical Center
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0002-3969-9782
    Expandedvalue
    Person Name
    Reber, Thomas
    @id
    https://orcid.org/0000-0002-3969-9782
    Scheme
    ORCID
    @type
    https://schema.org/Person
  5. Author Name
    Faber, Jennifer
    Author Affiliation
    University of Bonn Medical Center
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0003-3265-0262
    Expandedvalue
    Person Name
    Faber, Jennifer
    @id
    https://orcid.org/0000-0003-3265-0262
    Scheme
    ORCID
    @type
    https://schema.org/Person
  6. Author Name
    Elger, Christian E.
    Author Affiliation
    University of Bonn Medical Center
  7. Author Name
    Pals, Matthijs
    Author Affiliation
    Tübingen University
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0002-3051-1325
    Expandedvalue
    Person Name
    Pals, Matthijs
    @id
    https://orcid.org/0000-0002-3051-1325
    Scheme
    ORCID
    @type
    https://schema.org/Person
  8. Author Name
    Macke, Jakob H.
    Author Affiliation
    Tübingen University
  9. Author Name
    Boström, Jan
    Author Affiliation
    University of Bonn Medical Center
Dataset Contact datasetContact
  1. Dataset Contact Name
    Mormann, Florian
    Dataset Contact Affiliation
    University of Bonn Medical Center
    Dataset Contact Email
    florian.mormann@ukbonn.de
Ds Description dsDescription
  1. Ds Description Value
    The temporal order of a sequence of events has been thought to be reflected in the ordered firing of neurons at different phases of theta oscillations. Here we assess this by measuring single neuron activity (1,420 neurons) and local field potentials (921 channels) in the medial temporal lobe of 16 patients with epilepsy performing a working-memory task for temporal order. During memory maintenance, we observe theta oscillations, preferential firing of single neurons to theta phase and a close relationship between phase of firing and item position. However, the firing order did not match item order. Training recurrent neural networks to perform an analogous task, we also show the generation of theta oscillations, theta phase-dependent firing related to item position and, again, no match between firing and item order. Rather, our results suggest a mechanistic link between phase order, stimulus timing and oscillation frequency. In both biological and artificial neural networks, we provide evidence supporting the role of phase of firing in working-memory processing.
    Ds Description Date
    2025-03-24
Subject subject
  1. Medicine, Health and Life Sciences
Free Keyword freeKeyword
  1. Free Keyword Value
    Cognitive neuroscience
  2. Free Keyword Value
    Network models
  3. Free Keyword Value
    Working memory
Publication publication
  1. Publication Relation Type
    IsSupplementTo
    Publication Citation
    Liebe, S., Niediek, J., Pals, M. et al. Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks. Nat Neurosci 28, 873–882 (2025)
    Publication IDType
    doi
    Publication IDNumber
    10.1038/s41593-025-01893-7
    Publication URL
    https://doi.org/10.1038/s41593-025-01893-7
Depositor depositor
Walch, Sabrina
Date Of Deposit dateOfDeposit
2025-09-04

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