Transformations of the spatial activity manifold convey aversive information in CA3
type: Dataset
creator: Albert Miguel-Lopez
  type: Person
  given name: Albert
  family name: Miguel-Lopez
  affiliation: University of Bonn
creator: Negar Nikbahkt
  type: Person
  given name: Negar
  family name: Nikbahkt
  affiliation: University of Bonn
creator: Carlos Wert Carvajal
creator: Lena Johanna Gschossmann
  type: Person
  given name: Lena Johanna
  family name: Gschossmann
  affiliation: University of Bonn
creator: Martin Pofahl
  type: Person
  given name: Martin
  family name: Pofahl
  affiliation: University of Bonn
creator: Heinz Beck
creator: Tatjana Tchumatchenko
author: Albert Miguel-Lopez
  type: Person
  given name: Albert
  family name: Miguel-Lopez
  affiliation: University of Bonn
author: Negar Nikbahkt
  type: Person
  given name: Negar
  family name: Nikbahkt
  affiliation: University of Bonn
author: Carlos Wert Carvajal
author: Lena Johanna Gschossmann
  type: Person
  given name: Lena Johanna
  family name: Gschossmann
  affiliation: University of Bonn
author: Martin Pofahl
  type: Person
  given name: Martin
  family name: Pofahl
  affiliation: University of Bonn
author: Heinz Beck
author: Tatjana Tchumatchenko
date published: 2025-07-30
date modified: 2025-07-30
version: 1
description: Hippocampal circuits form cognitive maps representing spatial position and integrating contextual information, including affective cues, within episodic memory representations. We investigated how spatial and affective information combine in the population activity of CA3 axons by imaging intermediate-to-dorsal and dorsal-to-dorsal projections in mice navigating a linear track before, during, and after exposure to an aversive air puff stimulus. Our analyses reveal that both axonal populations maintain a robust, time-invariant spatial coding manifold across recordings, independent of affective context. Alterations to this common manifold encode the presence of the aversive stimulus without disrupting the spatial representation. Both axonal pathways encoded affective information with similar efficacy. This population-level encoding was distributed similarly across place and non-place cells. Our findings demonstrate that hippocampal CA3 axons integrate spatial and affective information within a common representational geometry while preserving the ability to extract each information type separately.
keywords: Medicine, Health and Life Sciences
citation: 2025.03.04.641439v1
license: http://creativecommons.org/licenses/by/4.0
included in data catalog: bonndata
publisher: bonndata
provider: bonndata
funder: Deutsche Forschungsgemeinschaft
distribution: Miguel-Lopez_Readme.txt
distribution: poetry.lock
distribution: pyproject.toml
distribution: README.md
distribution: APdecoding_funs.py
distribution: main_figures.py
distribution: mCCA.py
distribution: processing_functions.py
distribution: project_parameters.py
distribution: APdecoding_funs.cpython-39.pyc
distribution: main_functions.cpython-39.pyc
distribution: mCCA.cpython-39.pyc
distribution: processing_functions.cpython-39.pyc
distribution: project_parameters.cpython-39.pyc

Carlos Wert Carvajal
type: Person
given name: Carlos
family name: Wert Carvajal
affiliation: University of Bonn

Heinz Beck
type: Person
given name: Heinz
family name: Beck
affiliation: University of Bonn

Tatjana Tchumatchenko
type: Person
given name: Tatjana
family name: Tchumatchenko
affiliation: University of Bonn

2025.03.04.641439v1
type: CreativeWork
name: Albert Miguel-López, Negar Nikbahkt, Carlos Wert-Carvajal, Lena Johanna Gschossmann, Martin Pofahl, Heinz Beck, Tatjana Tchumatchenko. Transformations of the spatial activity manifold convey aversive information in CA3. bioRxiv 2025.03.04.641439; doi: https://doi.org/10.1101/2025.03.04.641439

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