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Transformations of the spatial activity manifold convey aversive information in CA3

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Persistent identifier
doi:10.60507/FK2/9TSLYB
Published version
1.0
Publication date
2025-07-30
License
CC BY 4.0

Description

Hippocampal circuits form cognitive maps representing spatial position and integrating contextual information, including affective cues, within episodic memory representations. We investigated how spatial and affective information combine in the population activity of CA3 axons by imaging intermediate-to-dorsal and dorsal-to-dorsal projections in mice navigating a linear track before, during, and after exposure to an aversive air puff stimulus. Our analyses reveal that both axonal populations maintain a robust, time-invariant spatial coding manifold across recordings, independent of affective context. Alterations to this common manifold encode the presence of the aversive stimulus without disrupting the spatial representation. Both axonal pathways encoded affective information with similar efficacy. This population-level encoding was distributed similarly across place and non-place cells. Our findings demonstrate that hippocampal CA3 axons integrate spatial and affective information within a common representational geometry while preserving the ability to extract each information type separately.

Creators

Keywords

computational neuroscience, hippocampal learning, aversive information, Hippocampus CA3, Hippocampus CA1

Files

Before downloading: Use and redistribution are governed by CC BY 4.0. Review and comply with the license before using the data.
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Citation

Albert Miguel-Lopez; Negar Nikbahkt; Carlos Wert Carvajal; Lena Johanna Gschossmann; Martin Pofahl; Heinz Beck; Tatjana Tchumatchenko, 2025-07-30, Transformations of the spatial activity manifold convey aversive information in CA3, doi:10.60507/FK2/9TSLYB, V1.0

Additional Dataverse fields

Id461
Dataset Typedataset
Internal Version Number30
Latest Version Publishing StateRELEASED
Release Time2025-07-30T13:10:10Z
Create Time2025-07-29T12:45:31Z
Citation Date2025-07-30
File Access RequestTrue

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Citation Metadata

Title title
Transformations of the spatial activity manifold convey aversive information in CA3
Alternative URL alternativeURL
https://github.com/amiguello/aversive_analysis_2025.git
Author author
  1. Author Name
    Albert Miguel-Lopez
    Author Affiliation
    University of Bonn
  2. Author Name
    Negar Nikbahkt
    Author Affiliation
    University of Bonn
  3. Author Name
    Carlos Wert Carvajal
    Author Affiliation
    University of Bonn
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0002-5340-8275
    Expandedvalue
    Person Name
    Wert Carvajal, Carlos
    @id
    https://orcid.org/0000-0002-5340-8275
    Scheme
    ORCID
    @type
    https://schema.org/Person
  4. Author Name
    Lena Johanna Gschossmann
    Author Affiliation
    University of Bonn
  5. Author Name
    Martin Pofahl
    Author Affiliation
    University of Bonn
  6. Author Name
    Heinz Beck
    Author Affiliation
    University of Bonn
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0002-8961-998X
    Expandedvalue
    Person Name
    Beck, Heinz
    @id
    https://orcid.org/0000-0002-8961-998X
    Scheme
    ORCID
    @type
    https://schema.org/Person
  7. Author Name
    Tatjana Tchumatchenko
    Author Affiliation
    University of Bonn
    Author Identifier Scheme
    ORCID
    Author Identifier
    Type Name
    authorIdentifier
    Multiple
    False
    Type Class
    primitive
    Value
    https://orcid.org/0000-0001-9137-809X
    Expandedvalue
    Person Name
    Tchumatchenko, Tatjana
    @id
    https://orcid.org/0000-0001-9137-809X
    Scheme
    ORCID
    @type
    https://schema.org/Person
Dataset Contact datasetContact
  1. Dataset Contact Name
    Tchumatchenko, Tatjana
    Dataset Contact Affiliation
    University of Bonn
    Dataset Contact Email
    ttchumat@uni-bonn.de
Ds Description dsDescription
  1. Ds Description Value
    Hippocampal circuits form cognitive maps representing spatial position and integrating contextual information, including affective cues, within episodic memory representations. We investigated how spatial and affective information combine in the population activity of CA3 axons by imaging intermediate-to-dorsal and dorsal-to-dorsal projections in mice navigating a linear track before, during, and after exposure to an aversive air puff stimulus. Our analyses reveal that both axonal populations maintain a robust, time-invariant spatial coding manifold across recordings, independent of affective context. Alterations to this common manifold encode the presence of the aversive stimulus without disrupting the spatial representation. Both axonal pathways encoded affective information with similar efficacy. This population-level encoding was distributed similarly across place and non-place cells. Our findings demonstrate that hippocampal CA3 axons integrate spatial and affective information within a common representational geometry while preserving the ability to extract each information type separately.
Subject subject
  1. Medicine, Health and Life Sciences
Free Keyword freeKeyword
  1. Free Keyword Value
    computational neuroscience
  2. Free Keyword Value
    hippocampal learning
  3. Free Keyword Value
    aversive information
  4. Free Keyword Value
    Hippocampus CA3
  5. Free Keyword Value
    Hippocampus CA1
Publication publication
  1. Publication Relation Type
    IsCitedBy
    Publication Citation
    Albert Miguel-López, Negar Nikbahkt, Carlos Wert-Carvajal, Lena Johanna Gschossmann, Martin Pofahl, Heinz Beck, Tatjana Tchumatchenko. Transformations of the spatial activity manifold convey aversive information in CA3. bioRxiv 2025.03.04.641439; doi: https://doi.org/10.1101/2025.03.04.641439
    Publication IDType
    arXiv
    Publication IDNumber
    10.1101/2025.03.04.641439v1
    Publication URL
    https://www.biorxiv.org/content/10.1101/2025.03.04.641439v1
Contributor contributor
  1. Contributor Type
    Data Collector
    Contributor Name
    Albert Miquel Lopez
  2. Contributor Type
    Data Collector
    Contributor Name
    Negar Nikbahkt
  3. Contributor Type
    Project Leader
    Contributor Name
    Heinz Beck
  4. Contributor Type
    Project Leader
    Contributor Name
    Tatjana Tchumatchenko
Grant Number grantNumber
  1. Grant Number Agency
    Deutsche Forschungsgemeinschaft
    Grant Number Value
    DFG
Depositor depositor
Tchumatchenko, Tatjana
Date Of Deposit dateOfDeposit
2025-07-29
Related Datasets relatedDatasets
  1. Nikbakht, N. et al. Efficient encoding of aversive location by ca3 long-range projections. Cell Reports 43, 113957 (2024). 10.1016/j.celrep.2024.113957

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