Clinical dataset on monocyte cholesterol crystal uptake and cyclodextrin exposure in patients undergoing coronary angiography
type: Dataset
creator: Luebbering, Nikola
creator: Zimmer, Sebastian
author: Luebbering, Nikola
author: Zimmer, Sebastian
date published: 2025-12-21
date modified: 2025-12-21
version: 1
description: This observational study includes patients undergoing diagnostic coronary angiography. For each participant we document demographic characteristics, cardiovascular risk factors, angiographic findings (presence and extent of CAD, PCI), laboratory markers of inflammation and metabolism, and medication at the time of the study. In addition, we assess cholesterol crystal (CC) uptake by circulating monocytes and the corresponding cyclodextrin (CD)-related effect (ΔCC) as imaging-/signal–derived measures. The overall purpose is to characterize this patient cohort and to examine whether CC uptake and its change are related to the burden of coronary artery disease and to clinically relevant parameters such as hypertension, diabetes mellitus, lipid profile, inflammatory markers (e.g. CRP, leukocytes) and current cardiovascular medication.
keywords: Medicine, Health and Life Sciences
keywords: Aortic Diseases
keywords: Monocytes
keywords: Cholesterol
keywords: Cyclodextrins
citation: journal.pone.0338635
license: http://creativecommons.org/licenses/by/4.0
included in data catalog: bonndata
publisher: bonndata
provider: bonndata
funder: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
distribution: S1_Data.csv
distribution: S1_Data_DataDictionary.csv
distribution: _Readme.txt

Luebbering, Nikola
type: Person
given name: Nikola
family name: Luebbering
affiliation: University of Bonn

Zimmer, Sebastian
type: Person
given name: Sebastian
family name: Zimmer
affiliation: University of Bonn

journal.pone.0338635
type: CreativeWork
name: Lübbering N, Krogmann A, Jansen F, Latz E, Nickenig G, Zimmer S (2025) Cyclodextrin reduces cholesterol crystal uptake by circulating monocytes in patients undergoing coronary angiography. PLoS One 20(12): e0338635.

S1_Data.csv
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encoding format: text/csv
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description: Data table. Header: true Delimiter: , (comma)

S1_Data_DataDictionary.csv
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encoding format: text/csv
content size: 3528
description: Data dictionary of S1_Data.csv. Header: true Delimiter: , (comma)

_Readme.txt
type: DataDownload
encoding format: text/plain
content size: 10482