Clinical dataset on monocyte cholesterol crystal uptake and cyclodextrin exposure in patients undergoing coronary angiography
This observational study includes patients undergoing diagnostic coronary angiography. For each participant we document demographic characteristics, cardiovascular risk factors, angiographic findings (presence and extent of CAD, PCI), laboratory markers of inflammation and metabolism, and medication at the time of the study. In addition, we assess cholesterol crystal (CC) uptake by circulating monocytes and the corresponding cyclodextrin (CD)-related effect (ΔCC) as imaging-/signal–derived measures. The overall purpose is to characterize this patient cohort and to examine whether CC uptake and its change are related to the burden of coronary artery disease and to clinically relevant parameters such as hypertension, diabetes mellitus, lipid profile, inflammatory markers (e.g. CRP, leukocytes) and current cardiovascular medication.
Lübbering N, Krogmann A, Jansen F, Latz E, Nickenig G, Zimmer S (2025) Cyclodextrin reduces cholesterol crystal uptake by circulating monocytes in patients undergoing coronary angiography. PLoS One 20(12): e0338635.
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
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