The Diagonal Band of Broca Regulates Olfactory-mediated Social Behaviors: A Study Using USVs As Unbiased, Ethological Markers For Social Interactions (doi:10.60507/FK2/WB6DOI)

View:

Part 1: Document Description
Part 2: Study Description
Part 5: Other Study-Related Materials
Entire Codebook

The Diagonal Band of Broca Regulates Olfactory-mediated Social Behaviors: A Study Using USVs As Unbiased, Ethological Markers For Social Interactions

doi:10.60507/FK2/WB6DOI

bonndata

2025-08-14

1

Mohammadi, Ali; Fuhrmann, Falko; Tillmann, Jens F.; Fuhrmann, Martin; Schwarz, Martin K., 2025, "The Diagonal Band of Broca Regulates Olfactory-mediated Social Behaviors: A Study Using USVs As Unbiased, Ethological Markers For Social Interactions", https://doi.org/10.60507/FK2/WB6DOI, bonndata, V1

The Diagonal Band of Broca Regulates Olfactory-mediated Social Behaviors: A Study Using USVs As Unbiased, Ethological Markers For Social Interactions

doi:10.60507/FK2/WB6DOI

Mohammadi, Ali (University of Bonn)

Fuhrmann, Falko (Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.)

Tillmann, Jens F. (University of Bonn)

Fuhrmann, Martin (Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.)

Schwarz, Martin K. (University of Bonn)

bonndata

Schwarz, Martin K.

Mohammadi, Ali

2025-08-13

https://doi.org/10.60507/FK2/WB6DOI

Medicine, Health and Life Sciences

The Horizontal Diagonal Band of Broca (HDB) modulates olfactory information processing by recruiting olfactory bulb (OB) interneurons to shape excitatory OB output. Here, we show that OB is strongly and differentially innervated by HDB projections. Light-induced silencing of HDB afferents in the OB via OPN3 affected olfactory-mediated social habituation and discrimination behaviors, as shown by manual annotation of investigative behavior. Additionally, we established ultrasonic vocalizations (USVs) as an unbiased, reliable, and ethologically relevant biomarker for quantifying investigative social behavior. To this end, we employed "DeepFisFis," an AI-based solution, developed in our lab for detection of mouse USVs. Collectively, our studies demonstrate that USVs serve as an effective biomarker for investigative social behavior. Furthermore, our results highlight the HDB as a crucial top-down relay in the modulation of olfactory-mediated social behaviors.

<a href="http://creativecommons.org/licenses/by/4.0">CC BY 4.0</a>

Schwarz, I. et al. The diagonal band of Broca regulates olfactory-mediated behaviours by modulating odor-evoked responses within the olfactory bulb. bioRxiv 2020.11.07.372649 (2020). https://doi.org/10.1101/2020.11.07.372649

10.1101/2020.11.07.372649

Schwarz, I. et al. The diagonal band of Broca regulates olfactory-mediated behaviours by modulating odor-evoked responses within the olfactory bulb. bioRxiv 2020.11.07.372649 (2020). https://doi.org/10.1101/2020.11.07.372649

Label:

Mohammadi_OB-OPN3_Readme.txt

text/plain

Label:

16726_SIT_0.h5

application/x-h5

Label:

16726_SIT_1.h5

application/x-h5

Label:

16726_SIT_2.h5

application/x-h5

Label:

16726_SIT_3.h5

application/x-h5

Label:

16726_SIT_4.h5

application/x-h5

Label:

16726_SIT_5.h5

application/x-h5

Label:

16727_SIT_0.h5

application/x-h5

Label:

16727_SIT_1.h5

application/x-h5

Label:

16727_SIT_2.h5

application/x-h5

Label:

16727_SIT_3.h5

application/x-h5

Label:

16727_SIT_4.h5

application/x-h5

Label:

16727_SIT_5.h5

application/x-h5

Label:

16753_SIT_0.h5

application/x-h5

Label:

16753_SIT_1.h5

application/x-h5

Label:

16753_SIT_2.h5

application/x-h5

Label:

16753_SIT_3.h5

application/x-h5

Label:

16753_SIT_4.h5

application/x-h5

Label:

16753_SIT_5.h5

application/x-h5

Label:

16754_SIT_0.h5

application/x-h5

Label:

16754_SIT_1.h5

application/x-h5

Label:

16754_SIT_2.h5

application/x-h5

Label:

16754_SIT_3.h5

application/x-h5

Label:

16754_SIT_4.h5

application/x-h5

Label:

16754_SIT_5.h5

application/x-h5

Label:

16755_SIT_0.h5

application/x-h5

Label:

16755_SIT_1.h5

application/x-h5

Label:

16755_SIT_2.h5

application/x-h5

Label:

16755_SIT_3.h5

application/x-h5

Label:

16755_SIT_4.h5

application/x-h5

Label:

16755_SIT_5.h5

application/x-h5

Label:

16756_SIT_0.h5

application/x-h5

Label:

16756_SIT_1.h5

application/x-h5

Label:

16756_SIT_2.h5

application/x-h5

Label:

16756_SIT_3.h5

application/x-h5

Label:

16756_SIT_4.h5

application/x-h5

Label:

16756_SIT_5.h5

application/x-h5

Label:

16757_SIT_0.h5

application/x-h5

Label:

16757_SIT_1.h5

application/x-h5

Label:

16757_SIT_2.h5

application/x-h5

Label:

16757_SIT_3.h5

application/x-h5

Label:

16757_SIT_4.h5

application/x-h5

Label:

16757_SIT_5.h5

application/x-h5

Label:

16887_SIT_0.h5

application/x-h5

Label:

16887_SIT_1.h5

application/x-h5

Label:

16887_SIT_2.h5

application/x-h5

Label:

16887_SIT_3.h5

application/x-h5

Label:

16887_SIT_4.h5

application/x-h5

Label:

16887_SIT_5.h5

application/x-h5

Label:

16888_SIT_0.h5

application/x-h5

Label:

16888_SIT_1.h5

application/x-h5

Label:

16888_SIT_2.h5

application/x-h5

Label:

16888_SIT_3.h5

application/x-h5

Label:

16888_SIT_4.h5

application/x-h5

Label:

16888_SIT_5.h5

application/x-h5

Label:

16889_SIT_0.h5

application/x-h5

Label:

16889_SIT_1.h5

application/x-h5

Label:

16889_SIT_2.h5

application/x-h5

Label:

16889_SIT_3.h5

application/x-h5

Label:

16889_SIT_4.h5

application/x-h5

Label:

16889_SIT_5.h5

application/x-h5

Label:

16890_SIT_0.h5

application/x-h5

Label:

16890_SIT_1.h5

application/x-h5

Label:

16890_SIT_2.h5

application/x-h5

Label:

16890_SIT_3.h5

application/x-h5

Label:

16890_SIT_4.h5

application/x-h5

Label:

16890_SIT_5.h5

application/x-h5

Label:

16939_SIT_0.h5

application/x-h5

Label:

16939_SIT_1.h5

application/x-h5

Label:

16939_SIT_2.h5

application/x-h5

Label:

16939_SIT_3.h5

application/x-h5

Label:

16939_SIT_4.h5

application/x-h5

Label:

16939_SIT_5.h5

application/x-h5

Label:

17095_SIT_0.h5

application/x-h5

Label:

17095_SIT_1.h5

application/x-h5

Label:

17095_SIT_2.h5

application/x-h5

Label:

17095_SIT_3.h5

application/x-h5

Label:

17095_SIT_4.h5

application/x-h5

Label:

17095_SIT_5.h5

application/x-h5

Label:

17096_SIT_0.h5

application/x-h5

Label:

17096_SIT_1.h5

application/x-h5

Label:

17096_SIT_2.h5

application/x-h5

Label:

17096_SIT_3.h5

application/x-h5

Label:

17096_SIT_4.h5

application/x-h5

Label:

17096_SIT_5.h5

application/x-h5

Label:

17098_SIT_0.h5

application/x-h5

Label:

17098_SIT_1.h5

application/x-h5

Label:

17098_SIT_2.h5

application/x-h5

Label:

17098_SIT_3.h5

application/x-h5

Label:

17098_SIT_4.h5

application/x-h5

Label:

17098_SIT_5.h5

application/x-h5

Label:

16726_SIT.avi

video/x-msvideo

Label:

16727_SIT.avi

video/x-msvideo

Label:

16753_SIT.avi

video/x-msvideo

Label:

16754_SIT.avi

video/x-msvideo

Label:

16755_SIT.avi

video/x-msvideo

Label:

16756_SIT.avi

video/x-msvideo

Label:

16757_SIT.avi

video/x-msvideo

Label:

16887_SIT.avi

video/x-msvideo

Label:

16888_SIT.avi

video/x-msvideo

Label:

16889_SIT.avi

video/x-msvideo

Label:

16890_SIT.avi

video/x-msvideo

Label:

16939_SIT.avi

video/x-msvideo

Label:

17095_SIT.avi

video/x-msvideo

Label:

17096_SIT.avi

video/x-msvideo

Label:

17098_SIT.avi

video/x-msvideo

Label:

16726_SIT.wav

audio/wav

Label:

16727_SIT.wav

audio/wav

Label:

16753_SIT.wav

audio/wav

Label:

16754_SIT.wav

audio/wav

Label:

16755_SIT.wav

audio/wav

Label:

16756_SIT.wav

audio/wav

Label:

16757_SIT.wav

audio/wav

Label:

16887_SIT.wav

audio/wav

Label:

16888_SIT.wav

audio/wav

Label:

16889_SIT.wav

audio/wav

Label:

16890_SIT.wav

audio/wav

Label:

16939_SIT.wav

audio/wav

Label:

17095_SIT.wav

audio/wav

Label:

17096_SIT.wav

audio/wav

Label:

17098_SIT.wav

audio/wav

Label:

16726_SIT_trials_borders.csv

text/csv

Label:

16727_SIT_trials_borders.csv

text/csv

Label:

16753_SIT_trials_borders.csv

text/csv

Label:

16754_SIT_trials_borders.csv

text/csv

Label:

16755_SIT_trials_borders.csv

text/csv

Label:

16756_SIT_trials_borders.csv

text/csv

Label:

16757_SIT_trials_borders.csv

text/csv

Label:

16887_SIT_trials_borders.csv

text/csv

Label:

16888_SIT_trials_borders.csv

text/csv

Label:

16889_SIT_trials_borders.csv

text/csv

Label:

16890_SIT_trials_borders.csv

text/csv

Label:

16939_SIT_trials_borders.csv

text/csv

Label:

17095_SIT_trials_borders.csv

text/csv

Label:

17096_SIT_trials_borders.csv

text/csv

Label:

17098_SIT_trials_borders.csv

text/csv

Label:

16726_SIT_USV_intervals.csv

text/csv

Label:

16727_SIT_USV_intervals.csv

text/csv

Label:

16753_SIT_USV_intervals.csv

text/csv

Label:

16754_SIT_USV_intervals.csv

text/csv

Label:

16755_SIT_USV_intervals.csv

text/csv

Label:

16756_SIT_USV_intervals.csv

text/csv

Label:

16757_SIT_USV_intervals.csv

text/csv

Label:

16887_SIT_USV_intervals.csv

text/csv

Label:

16888_SIT_USV_intervals.csv

text/csv

Label:

16889_SIT_USV_intervals.csv

text/csv

Label:

16890_SIT_USV_intervals.csv

text/csv

Label:

16939_SIT_USV_intervals.csv

text/csv

Label:

17095_SIT_USV_intervals.csv

text/csv

Label:

17096_SIT_USV_intervals.csv

text/csv

Label:

17098_SIT_USV_intervals.csv

text/csv