Transformations of the spatial activity manifold convey aversive information in CA3 (doi:10.60507/FK2/9TSLYB)

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Transformations of the spatial activity manifold convey aversive information in CA3

doi:10.60507/FK2/9TSLYB

bonndata

2025-07-30

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Albert Miguel-Lopez; Negar Nikbahkt; Carlos Wert Carvajal; Lena Johanna Gschossmann; Martin Pofahl; Heinz Beck; Tatjana Tchumatchenko, 2025, "Transformations of the spatial activity manifold convey aversive information in CA3", https://doi.org/10.60507/FK2/9TSLYB, bonndata, V1

Transformations of the spatial activity manifold convey aversive information in CA3

doi:10.60507/FK2/9TSLYB

Albert Miguel-Lopez (University of Bonn)

Negar Nikbahkt (University of Bonn)

Carlos Wert Carvajal (University of Bonn)

Lena Johanna Gschossmann (University of Bonn)

Martin Pofahl (University of Bonn)

Heinz Beck (University of Bonn)

Tatjana Tchumatchenko (University of Bonn)

Albert Miquel Lopez

Negar Nikbahkt

Heinz Beck

Tatjana Tchumatchenko

DFG

bonndata

Tchumatchenko, Tatjana

Tchumatchenko, Tatjana

2025-07-29

https://doi.org/10.60507/FK2/9TSLYB

Medicine, Health and Life Sciences, Medicine, Health and Life Sciences

Hippocampal circuits form cognitive maps representing spatial position and integrating contextual information, including affective cues, within episodic memory representations. We investigated how spatial and affective information combine in the population activity of CA3 axons by imaging intermediate-to-dorsal and dorsal-to-dorsal projections in mice navigating a linear track before, during, and after exposure to an aversive air puff stimulus. Our analyses reveal that both axonal populations maintain a robust, time-invariant spatial coding manifold across recordings, independent of affective context. Alterations to this common manifold encode the presence of the aversive stimulus without disrupting the spatial representation. Both axonal pathways encoded affective information with similar efficacy. This population-level encoding was distributed similarly across place and non-place cells. Our findings demonstrate that hippocampal CA3 axons integrate spatial and affective information within a common representational geometry while preserving the ability to extract each information type separately.

<a href="http://creativecommons.org/licenses/by/4.0">CC BY 4.0</a>

Nikbakht, N. et al. Efficient encoding of aversive location by ca3 long-range projections. Cell Reports 43, 113957 (2024). 10.1016/j.celrep.2024.113957

Albert Miguel-López, Negar Nikbahkt, Carlos Wert-Carvajal, Lena Johanna Gschossmann, Martin Pofahl, Heinz Beck, Tatjana Tchumatchenko. Transformations of the spatial activity manifold convey aversive information in CA3. bioRxiv 2025.03.04.641439; doi: https://doi.org/10.1101/2025.03.04.641439

10.1101/2025.03.04.641439v1

Albert Miguel-López, Negar Nikbahkt, Carlos Wert-Carvajal, Lena Johanna Gschossmann, Martin Pofahl, Heinz Beck, Tatjana Tchumatchenko. Transformations of the spatial activity manifold convey aversive information in CA3. bioRxiv 2025.03.04.641439; doi: https://doi.org/10.1101/2025.03.04.641439

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